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INDUCED MODELS - MODEL BACKGROUND

Functional Knock out/ Genetic Variants

  • ​PSEN1 M146V Alzheimer's

  • ATG7 NASH

  • GPR-39, GPR-19 Knockouts

  • WNK1, CYK2, SRC, Protein Kinase C Knockouts

  • Potassium and Sodium channel SCN8A Knockouts

 Gain of Toxic/Loss of Function

  • PolyQ CAG repeats Spinocerebellar Ataxia

  • Parkinson’s alpha synuclein and Tau aggregate models

  • SOD-1 aggregates in ALS

  • Phenylketonuria Serine349Pro

Inflammatory Tumour/Infection

  • ​Humanized PBMC Grafted Model

  • Humanized Hematopoietic Stem Cells Grafted Model

  • T & B cells lacking Model

  • KRAS duplication Models

  • BRCA deficient Model

  • Cell Line Transplants NSCLC, HER2+ve Model

  • SARS-CoV2, Dengue

  • High Calorie High Carb Type II Diabetes

  • High Fat High Carb NASH

  • Obesity induced inflammatory bowel disease

Feed Induced Model

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