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Zebrafish genetic variants with a full functional physiology analyzed by AI hardware.

Target Modulation

Get Realtime feeback on Receptor Response

Efficacy Screening

Prove mechanism of action through dose response curves

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Neurofibromatosis – Type 1  

Drug Discovery Challenge and Solutions

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Obesity Drug Discovery

Without off target CNS effect

Kinetics and Biodistribution

Know targeted delivery and off target accumulations

Phenotype Rescue

Target Deconvolution methods to demonstrate rescue

​GBA modulators

Preventing Neuronal Death with Zebrafish Assays

Restoring Functional AAT Protein

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Safety Toxicolgoy

Know early, Make decisions early !

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WHY ZEBRAFISH

Human disease course of several months happens in two weeks in zebrafish

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 Learn how zebrafish endpoints compare to humans and other research models.
 

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FDA Releases Draft Guidance on Alternatives to Animal Testing in Drug Development -March 18, 2026​

​​The 4 Validation Principles for Submission Criteria

Context of Use

Defines the exact scientific question the NAM answers (e.g., assessing hepatotoxicity during clinical trials or setting safe starting doses).

Human Biological Relevance

Requires sponsors to justify cell types, species of origin, and physiological features to prove the model mirrors human in vivo toxicity.

Technical Characterization

Demands rigorous documentation of assay parameters, limits of detection, reference compound controls, and sources of batch variability.

Fit-for-Purpose

Assures the data can directly drive regulatory drug reviews, either as a standalone alternative or within a broader total weight-of-evidence package.

Read how we drive change in your candidate development process

November 2024

Studying Protein Aggregates with Zebrafish

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